Selgian (other name Eldepryl)

Common use

Eldepryl is a monoamine oxidase inhibitor, which used to treat the symptoms of Parkinson's disease. This is a case of the brain that affects motion. People with Parkinson's disease do not have enough nerve cells in the part of the brain that controls movement. These nerve cells produce a substance called dopamine. It is a lack of dopamine which causes problems with movement. Eldepryl tablets keep dopamine around longer, helping with difficulties in movement. Eldepryl has no anti-Parkinson effects of its own and must always be given in combination with levodopa/carbidopa.

Dosage and direction

Take it orally every day after breakfast and lunch. Do not drink or eat anything for at least 5 minutes after taking a Eldepryl orally disintegrating tablet.
The recommended dose for adults is 10 mg per day divided into 2 smaller doses of 5 mg.
It's very necessary to consult with your doctor before using. It help you to get best results.

Precautions

You must not eat foods that are high in tyramine, including: pickled herring, air dried meats, aged or fermented meats, poultry, sausage or salami, and any spoiled or improperly stored beef, fish, or liver; aged cheeses, including blue, brick, boursault, brie, cheddar, camembert, emmenthaler, parmesan, romano, gruyere, roquefort, stilton and swiss; beer from a tap, beer that has not been pasteurized; over-the-counter supplements or cough and cold medicines that contain tyramine; sauerkraut, soy beans, soy sauce, tofu, miso soup, bean curd, fava beans; or yeast extracts.
Eating tyramine while you are taking this drug can increase your blood pressure to dangerous levels which could cause life-threatening side effects.
Eldepryl should be administered cautiously to patients with peptic or duodenal ulcer, labile hypertension, cardiac arrhythmias, severe angina pectoris, severe liver or kidney dysfunction or psychosis. In higher doses (>30 mg daily) the attenuation of selegiline begins to decrease resulting in increased inhibition of MAO-A. Lightheadedness, dizziness, or fainting may intervene, especially when you get up from a lying or sitting position. So you may get up slowly, but if the problem continues or gets worse, consult to your doctor.
Eldepryl should not be used during pregnancy, becoming pregnant or lactating without doctor's advice. Do not use Eldepryl before breast-feeding without doctor's permission.

Contraindications

Eldepryl is not allowed to people who are hypersensitive to selegiline or other components of the formulation. Do not take Demedrol or such types of narcotic while you are taking Eldepryl.
Also do not use Eldepryl if you have used any of the following drugs within the past 14 days: meperidine, propoxyphene or tramadol, methadone, cough or cold medicine that contains dextromethorphan or other MAO inhibitors such as isocarboxazid, tranylcypromine, phenelzine, rasagiline or transdermal selegiline.

Possible side effect

They may include all types of an allergic reaction. Also the most possible side effects include:
confusion, sudden and severe headache, blurred vision, nausea, problems with speech or balance, vomiting, seizure, chest pain and sudden numbness or weakness;
feeling light-headed, fainting;
hallucinations;
feeling restless, agitated, or irritable;
twitching muscle movements;
painful or difficult urination.

Less serious include:
dizziness, weakness;
sleep problems (insomnia);
runny or stuffy nose;
back pain;
constipation.

Drug interaction

Eldepryl interact with the following list of drugs: diet pills or cold medicines that contain ephedrine, pseudoephedrine, or phenylephrine; carbamazepine; nafcillin; rifampin; an antidepressant such as amitriptyline, amoxapine, bupropion, citalopram, clomipramine, desipramine, doxepin, duloxetine, escitalopram, fluoxetine, fluvoxamine, imipramine, nortriptyline, paroxetine, protriptyline, sertraline, venlafaxine or trimipramine; phenobarbital.
Also note that interaction between two medications does not always mean that you must stop taking one of them. As usual it affects the the effect of drugs, so consult with your doctor about how it interactions are being managed or should be managed.

Missed dose

If you forgot to take your dose in time, please do it as soon as you remember. But do not take if it is too late or almost time for your next dose. Do not increase your recommended dose. Take your usually dose next day in the same regularly time.

Overdose

Symptoms of Eldepryl overdose may include severe headache, vision problems, sweating, hallucinations, feeling light-headed, cool or clammy skin, fast or uneven heart rate, fainting or seizure.
If you experience one of them or any unusual symptoms call your doctor immediately.

Storage

Store at room temperature between 20-25 C (68-77 F).